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KMID : 1123920020160020332
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 2 p.332 ~ p.337
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Study on Antitumor and Immunomodulatory Effects of Cambodian Phellinus linteus
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Lee Hyo-Jeong
Park Jung-Min
Song Gyu-Yong
Kang Kyung-Sun
Kim Sung-Hoon
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Abstract
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Phellinus Iinteus from Cambodia was confirmed to have a homologous DNA sequencec to Phellinus Iinteus. Antitumor and immunomodulatory activities were evaluated with aquous extract of Cambodian Phellinus Iinteus(CPL). CPL didn’t show any significant cytotoxicity on HT1080, Sarcoma 180 and B16BL6, whereas it inhibited the relaxation of DNA topoisomerase I from the concentration of 250ug/ml. In the pulmonary colonization assay it inhibited pulmonary metastasis by B16BL6 in C57BL6 mice to 36%, 36.9% and 55.5% at various doses of 2 mg, 20 mg and 50 mg. From FACS analysis with splenocytes pretreated with CPL, it significantly increased lymphoblast and induced production of IL-2. These results indicate Cambodian Phellinus Iinteus has antitumor and immunomodulatory activities still suggesting more study on its mechanism and effective compound in detail.
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KEYWORD
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Antitumor, immunomodulatory, Phellinus Iinteus
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